Near-Native Protein Loop Sampling Using Nonparametric Density Estimation Accommodating Sparcity

Unlike the core structural elements of a protein like regular secondary structure, template based modeling (TBM) has difficulty with loop regions due to their variability in sequence and structure as well as the sparse sampling from a limited number of homologous templates. We present a novel, knowl...

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Bibliographic Details
Main Authors: Joo, Hyun, Chavan, Archana G., Day, Ryan, Lennox, Kristin P., Sukhanov, Paul, Dahl, David B., Vannucci, Marina, Tsai, Jerry
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197639/
https://ncbi.nlm.nih.gov/pubmed/22028638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002234
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