DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation

BACKGROUND: Cumulative evidence suggests that DNA secondary structures impact DNA replication, transcription and genomic rearrangements. One of the best studied examples is the recurrent constitutional t(11;22) in humans that is mediated by potentially cruciform-forming sequences at the breakpoints,...

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Main Authors: Kato, Takema, Inagaki, Hidehito, Tong, Maoqing, Kogo, Hiroshi, Ohye, Tamae, Yamada, Kouji, Tsutsumi, Makiko, Emanuel, Beverly S, Kurahashi, Hiroki
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197554/
https://ncbi.nlm.nih.gov/pubmed/21899780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8166-4-18
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