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Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro

Tenderness and mechanical allodynia are key symptoms of malignant tumor, inflammation and neuropathy. The proinflammatory cytokine interleukin-6 (IL-6) is causally involved in all three pathologies. IL-6 not only regulates innate immunity and inflammation but also causes nociceptor sensitization and...

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Bibliografski detalji
Glavni autori: Quarta, Serena, Vogl, Christian, Constantin, Cristina E, Üçeyler, Nurcan, Sommer, Claudia, Kress, Michaela
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197546/
https://ncbi.nlm.nih.gov/pubmed/21951917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-73
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