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Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro

Tenderness and mechanical allodynia are key symptoms of malignant tumor, inflammation and neuropathy. The proinflammatory cytokine interleukin-6 (IL-6) is causally involved in all three pathologies. IL-6 not only regulates innate immunity and inflammation but also causes nociceptor sensitization and...

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Détails bibliographiques
Auteurs principaux: Quarta, Serena, Vogl, Christian, Constantin, Cristina E, Üçeyler, Nurcan, Sommer, Claudia, Kress, Michaela
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197546/
https://ncbi.nlm.nih.gov/pubmed/21951917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-73
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