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Carboxyl Terminated PAMAM-SN38 Conjugates: Synthesis, Characterization, and In vitro Evaluation
In the present work, carboxyl terminated PAMAM G-3.5 was covalently attached to SN38 via glycine and β-alanine spacers. The conjugates were stable at pH 7.4 and moderately hydrolyzed in cell culture media and rat plasma. Similar to SN38 but to a lesser extent, both conjugates inhibited proliferation...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197241/ https://ncbi.nlm.nih.gov/pubmed/20836544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc100094z |
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