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PAMAM-Camptothecin Conjugate Inhibits Proliferation and Induces Nuclear Fragmentation in Colorectal Carcinoma Cells
PURPOSE: To synthesize and characterize a poly (amido amine) dendrimer-camptothecin (PAMAM-CPT) conjugate and evaluate its activity on human colorectal carcinoma cells (HCT-116). METHODS: The attachment of CPT to amine-terminated PAMAM was facilitated through a succinic acid-glycine linker. The conj...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092430/ https://ncbi.nlm.nih.gov/pubmed/20552256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-010-0179-6 |
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