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The desmin coil 1B mutation K190A impairs nebulin Z-disc assembly and destabilizes actin thin filaments
Desmin intermediate filaments intimately surround myofibrils in vertebrate muscle forming a mesh-like filament network. Desmin attaches to sarcomeres through its high-affinity association with nebulin, a giant F-actin binding protein that co-extends along the length of actin thin filaments. Here, we...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196858/ https://ncbi.nlm.nih.gov/pubmed/21984811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.087080 |
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