HLA-DR(+) CD38(+) CD4(+) T Lymphocytes Have Elevated CCR5 Expression and Produce the Majority of R5-Tropic HIV-1 RNA In Vivo

Percentages of activated T cells correlate with HIV-1 disease progression, but the underlying mechanisms are not fully understood. We hypothesized that HLA-DR(+) CD38(+) (DR(+) 38(+)) CD4(+) T cells produce the majority of HIV-1 due to elevated expression of CCR5 and CXCR4. In phytohemagglutinin (PH...

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Main Authors: Meditz, Amie L., Haas, Michelle K., Folkvord, Joy M., Melander, Kelsey, Young, Russ, McCarter, Martin, MaWhinney, Samantha, Campbell, Thomas B., Lie, Yolanda, Coakley, Eoin, Levy, David N., Connick, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196402/
https://ncbi.nlm.nih.gov/pubmed/21813616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02529-10
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