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SDF-1α Is a Potent Inducer of HIV-1-Specific CD8(+) T-Cell Chemotaxis, But Migration of CD8(+) T Cells Is Impaired at High Viral Loads

Multiple impairments in HIV-1-specific cytotoxic T cells (CTL) have been reported, but derangements in HIV-1-specific CD8(+) T-cell chemotaxis have not been described previously. We assessed migration to SDF-1α (stromal cell-derived factor 1-alpha) and CX3CL1 in vitro and expression of cognate recep...

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Dettagli Bibliografici
Autori principali: Meditz, Amie L., Schlichtemeier, Rick, Folkvord, Joy M., Givens, Monique, Lesh, Kevin C., Ray, M.G., McCarter, Martin D., Connick, Elizabeth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927034/
https://ncbi.nlm.nih.gov/pubmed/18671480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2007.0259
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