Generation of Replication-Defective Virus-Based Vaccines That Confer Full Protection in Sheep against Virulent Bluetongue Virus Challenge

The reverse genetics technology for bluetongue virus (BTV) has been used in combination with complementing cell lines to recover defective BTV-1 mutants. To generate a potential disabled infectious single cycle (DISC) vaccine strain, we used a reverse genetics system to rescue defective virus strain...

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Autors principals: Matsuo, Eiko, Celma, Cristina C. P., Boyce, Mark, Viarouge, Cyril, Sailleau, Corinne, Dubois, Eric, Bréard, Emmanuel, Thiéry, Richard, Zientara, Stéphan, Roy, Polly
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196398/
https://ncbi.nlm.nih.gov/pubmed/21795358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05412-11
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