Generation of Replication-Defective Virus-Based Vaccines That Confer Full Protection in Sheep against Virulent Bluetongue Virus Challenge

The reverse genetics technology for bluetongue virus (BTV) has been used in combination with complementing cell lines to recover defective BTV-1 mutants. To generate a potential disabled infectious single cycle (DISC) vaccine strain, we used a reverse genetics system to rescue defective virus strain...

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Bibliographische Detailangaben
Hauptverfasser: Matsuo, Eiko, Celma, Cristina C. P., Boyce, Mark, Viarouge, Cyril, Sailleau, Corinne, Dubois, Eric, Bréard, Emmanuel, Thiéry, Richard, Zientara, Stéphan, Roy, Polly
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196398/
https://ncbi.nlm.nih.gov/pubmed/21795358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05412-11
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