NEW TARGET FOR INHIBITION OF BACTERIAL RNA POLYMERASE: "SWITCH REGION"

A new drug target-- the "switch region"--has been identified within bacterial RNA polymerase (RNAP), the enzyme that mediates bacterial RNA synthesis. The new target serves as the binding site for compounds that inhibit bacterial RNA synthesis and kill bacteria. Since the new target is pre...

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Autors principals: Srivastava, Aashish, Talaue, Meliza, Liu, Shuang, Degen, David, Ebright, Richard Y., Sineva, Elena, Chakraborty, Anirban, Druzhinin, Sergey Y., Chatterjee, Sujoy, Mukhopadhyay, Jayanta, Ebright, Yon W., Zozula, Alex, Shen, Juan, Sengupta, Sonali, Niedfeldt, Rui Rong, Xin, Cai, Kaneko, Takushi, Irschik, Herbert, Jansen, Rolf, Donadio, Stefano, Connell, Nancy, Ebright, Richard H.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196380/
https://ncbi.nlm.nih.gov/pubmed/21862392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mib.2011.07.030
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