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Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin
The chemical step in the chemoenzymatic synthesis of bioengineered heparin has been examined and optimized statistically using a response surface methodology. A four factor, two level full factorial design experiment and a three factor Box-Behnken design were carried out. The goal was to establish a...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196266/ https://ncbi.nlm.nih.gov/pubmed/21925548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiotec.2011.08.013 |
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