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Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin

The chemical step in the chemoenzymatic synthesis of bioengineered heparin has been examined and optimized statistically using a response surface methodology. A four factor, two level full factorial design experiment and a three factor Box-Behnken design were carried out. The goal was to establish a...

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Bibliografski detalji
Glavni autori: Wang, Zhenyu, Li, Jennifer, Cheong, Samantha, Bhaskar, Ujjwal, Akihiro, Onishi, Zhang, Fuming, Dordick, Jonathan S., Linhardt, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196266/
https://ncbi.nlm.nih.gov/pubmed/21925548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiotec.2011.08.013
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