Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis

Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the “high-capacity binding site” (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation. Here, using sucrose gradient fractionation, we obtained evidence that both ABCA1 and [(125)I]apoA-...

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Detalhes bibliográficos
Main Authors: Iatan, Iulia, Bailey, Dana, Ruel, Isabelle, Hafiane, Anouar, Campbell, Steven, Krimbou, Larbi, Genest, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196236/
https://ncbi.nlm.nih.gov/pubmed/21846716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M016196
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