Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-talk Is Essential for Toll-like Receptor Activation and Cellular Signaling

The signaling pathways of mammalian Toll-like receptors (TLRs) are well characterized, but the precise mechanism(s) by which TLRs are activated upon ligand binding remains poorly defined. Recently, we reported a novel membrane sialidase-controlling mechanism that depends on ligand binding to its TLR...

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Detalhes bibliográficos
Main Authors: Abdulkhalek, Samar, Amith, Schammim Ray, Franchuk, Susan L., Jayanth, Preethi, Guo, Merry, Finlay, Trisha, Gilmour, Alanna, Guzzo, Christina, Gee, Katrina, Beyaert, Rudi, Szewczuk, Myron R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196117/
https://ncbi.nlm.nih.gov/pubmed/21873432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237578
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