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Anti-Ro52 Autoantibodies from Patients with Sjögren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface

Ro52 (TRIM21) is an E3 ligase of the tripartite motif family that negatively regulates proinflammatory cytokine production by ubiquitinating transcription factors of the interferon regulatory factor family. Autoantibodies to Ro52 are present in patients with lupus and Sjögren's syndrome, but it...

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Dettagli Bibliografici
Autori principali: Espinosa, Alexander, Hennig, Janosch, Ambrosi, Aurélie, Anandapadmanaban, Madhanagopal, Abelius, Martina Sandberg, Sheng, Yi, Nyberg, Filippa, Arrowsmith, Cheryl H., Sunnerhagen, Maria, Wahren-Herlenius, Marie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196112/
https://ncbi.nlm.nih.gov/pubmed/21862588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241786
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