Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor α Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction

Septic shock results from bacterial infection and is associated with multi-organ failure, high mortality, and cardiac dysfunction. Sepsis causes both myocardial inflammation and energy depletion. We hypothesized that reduced cardiac energy production is a primary cause of ventricular dysfunction in...

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Autors principals: Drosatos, Konstantinos, Drosatos-Tampakaki, Zoi, Khan, Raffay, Homma, Shunichi, Schulze, P. Christian, Zannis, Vassilis I., Goldberg, Ira J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196095/
https://ncbi.nlm.nih.gov/pubmed/21873422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272146
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