The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein

BACKGROUND AND PURPOSE: AM251 is an inverse agonist of the cannabinoid 1 receptor (CB(1)R) that can exert ‘off-target’ effects in vitro and in CB(1)R knock-out mice. AM251 is also potent at modulating tumour cell growth, suggesting that growth factor-mediated oncogenic signalling could be regulated...

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Detalhes bibliográficos
Main Authors: Fiori, JL, Sanghvi, M, O'Connell, MP, Krzysik-Walker, SM, Moaddel, R, Bernier, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195923/
https://ncbi.nlm.nih.gov/pubmed/21449913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01384.x
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