POTENTIAL ANXIOGENIC EFFECTS OF CANNABINOID CB1 RECEPTOR ANTAGONISTS/INVERSE AGONISTS IN RATS: COMPARISONS BETWEEN AM4113, AM251, AND THE BENZODIAZEPINE INVERSE AGONIST FG-7142

Cannabinoid CB1 inverse agonists suppress food-motivated behaviors, but may also induce psychiatric effects such as depression and anxiety. To evaluate behaviors potentially related to anxiety, the present experiments assessed the CB1 inverse agonist AM251 (2.0 – 8.0 mg/kg), the CB1 antagonist AM411...

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Main Authors: Sink, KS, Segovia, KN, Sink, J, Randall, PA, Collins, LE, Correa, M, Markus, EJ, Vemuri, VK, Makriyannis, A, Salamone, JD
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817975/
https://ncbi.nlm.nih.gov/pubmed/20015619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euroneuro.2009.11.002
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