Variability in response to clopidogrel: how important are pharmacogenetics and drug interactions?

Clopidogrel is a pro-drug which is converted to an active metabolite that selectively blocks ADP-dependent platelet activation and aggregation. The main enzyme responsible for activating clopidogrel is the cytochrome P450 (CYP) isoenzyme CYP2C19, which is polymorphic. There is a growing body of lite...

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Detalhes bibliográficos
Main Authors: Ma, Terry K W, Lam, Yat-Yin, Tan, Victoria P, Yan, Bryan P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Haemostasis Themed Issue
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195744/
https://ncbi.nlm.nih.gov/pubmed/21352268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03949.x
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