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Variability in response to clopidogrel: how important are pharmacogenetics and drug interactions?
Clopidogrel is a pro-drug which is converted to an active metabolite that selectively blocks ADP-dependent platelet activation and aggregation. The main enzyme responsible for activating clopidogrel is the cytochrome P450 (CYP) isoenzyme CYP2C19, which is polymorphic. There is a growing body of lite...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Science Inc
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3195744/ https://ncbi.nlm.nih.gov/pubmed/21352268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03949.x |
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