Hepatic calcium efflux during cytochrome P-450-dependent drug oxidations at the endoplasmic reticulum in intact liver.

During metabolism of (type I) drugs by cytochrome P-450-dependent monooxygenase of the endoplasmic reticulum, the NADPH/NADP+ ratio in rat liver selectively decreases to approximately one-half of the control values, whereas the NADH/NAD+ ratio remains practically unaffected [Sies, H. & Brauser,...

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Bibliographic Details
Main Authors: Sies, H, Graf, P, Estrela, J M
Format: Artigo
Language:Inglês
Published: 1981
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC319567/
https://ncbi.nlm.nih.gov/pubmed/6943544
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