Group V Phospholipase A(2) in Bone Marrow-derived Myeloid Cells and Bronchial Epithelial Cells Promotes Bacterial Clearance after Escherichia coli Pneumonia

Group V-secreted phospholipase A(2) (GV sPLA(2)) hydrolyzes bacterial phospholipids and initiates eicosanoid biosynthesis. Here, we elucidate the role of GV sPLA(2) in the pathophysiology of Escherichia coli pneumonia. Inflammatory cells and bronchial epithelial cells both express GV sPLA(2) after p...

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Autores principales: Degousee, Norbert, Kelvin, David J., Geisslinger, Gerd, Hwang, David M., Stefanski, Eva, Wang, Xing-Hua, Danesh, Ali, Angioni, Carlo, Schmidt, Helmut, Lindsay, Thomas F., Gelb, Michael H., Bollinger, James, Payré, Christine, Lambeau, Gérard, Arm, Jonathan P., Keating, Armand, Rubin, Barry B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195628/
https://ncbi.nlm.nih.gov/pubmed/21849511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262733
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