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Platelet-derived Growth Factor (PDGF) Regulates Slingshot Phosphatase Activity via Nox1-dependent Auto-dephosphorylation of Serine 834 in Vascular Smooth Muscle Cells

Migration of vascular smooth muscle cells (VSMCs) contributes to vascular pathology. PDGF induces VSMC migration by a Nox1-based NADPH oxidase mediated mechanism. We have previously shown that PDGF-induced migration in VSMCs requires Slingshot-1L (SSH1L) phosphatase activity. In the present work, th...

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Main Authors: Maheswaranathan, Mithunan, Gole, Hope K. A., Fernandez, Isabel, Lassègue, Bernard, Griendling, Kathy K., San Martín, Alejandra
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195626/
https://ncbi.nlm.nih.gov/pubmed/21857021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268284
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