Cellular Iron Depletion and the Mechanisms Involved in the Iron-dependent Regulation of the Growth Arrest and DNA Damage Family of Genes

Iron plays a crucial part in proliferation while iron deficiency results in G(1)/S arrest, DNA damage, and apoptosis. However, the precise role of iron in cell cycle control remains unclear. We showed that iron depletion using the iron chelators, desferrioxamine (DFO), or 2-hydroxy-1-napthylaldehyde...

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Bibliographische Detailangaben
Hauptverfasser: Saletta, Federica, Rahmanto, Yohan Suryo, Siafakas, Aritee R., Richardson, Des R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195607/
https://ncbi.nlm.nih.gov/pubmed/21852233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.273060
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