Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism

The botulinum neurotoxins (BoNTs) are di-chain bacterial proteins responsible for the paralytic disease botulism. Following binding to the plasma membrane of cholinergic motor nerve terminals, BoNTs are internalized into an endocytic compartment. Although several endocytic pathways have been charact...

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Hlavní autoři: Harper, Callista B., Martin, Sally, Nguyen, Tam H., Daniels, Shari J., Lavidis, Nickolas A., Popoff, Michel R., Hadzic, Gordana, Mariana, Anna, Chau, Ngoc, McCluskey, Adam, Robinson, Phillip J., Meunier, Frederic A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195592/
https://ncbi.nlm.nih.gov/pubmed/21832053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283879
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