Unbinding of Hyaluronan Accelerates the Enzymatic Activity of Bee Hyaluronidase

Hyaluronan (HA), a polymeric glycosaminoglycan ubiquitously present in higher animals, is hydrolyzed by hyaluronidases (HAases). Here, we used bee HAase as a model enzyme to study the HA-HAase interaction. Located in close proximity to the active center, a bulky surface loop, which appears to obstru...

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Dettagli Bibliografici
Autori principali: Iliás, Attila, Liliom, Károly, Greiderer-Kleinlercher, Brigitte, Reitinger, Stephan, Lepperdinger, Günter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195588/
https://ncbi.nlm.nih.gov/pubmed/21840987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.263731
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