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Designed Human Serum Hyaluronidase 1 Variant, HYAL1(ΔL), Exhibits Activity up to pH 5.9
Hyaluronidases from diverse species and sources have different pH optima. Distinct mechanisms with regard to dynamic structural changes, which control hyaluronidase activity at varying pH, are unknown. Human serum hyaluronidase 1 (HYAL1) is active solely below pH 5.1. Here we report the design of a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740539/ https://ncbi.nlm.nih.gov/pubmed/19478093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.004358 |
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