Designed Human Serum Hyaluronidase 1 Variant, HYAL1(ΔL), Exhibits Activity up to pH 5.9

Hyaluronidases from diverse species and sources have different pH optima. Distinct mechanisms with regard to dynamic structural changes, which control hyaluronidase activity at varying pH, are unknown. Human serum hyaluronidase 1 (HYAL1) is active solely below pH 5.1. Here we report the design of a...

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Bibliografiske detaljer
Main Authors: Reitinger, Stephan, Müllegger, Johannes, Greiderer, Brigitte, Nielsen, Jens Erik, Lepperdinger, Günter
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Accelerated Publications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740539/
https://ncbi.nlm.nih.gov/pubmed/19478093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.004358
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