Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

TANK-binding kinase (TBK1) is essential for transcription of the interferon (IFN) β gene in response to lipopolysaccharide (LPS) and double-stranded RNA, but the molecular mechanisms that underlie the activation of TBK1 are incompletely understood. Previously, we identified the NF-κB essential modul...

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Bibliographic Details
Main Authors: Gleason, Catherine E., Ordureau, Alban, Gourlay, Robert, Arthur, J. Simon C., Cohen, Philip
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195586/
https://ncbi.nlm.nih.gov/pubmed/21862579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.267567
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