Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs

CP-31398 (N′-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride) is a styrylquinazoline that stabilizes the DNA binding conformation of p53, thereby maintaining the activity of p53 as a transcription factor and tumor suppressor. In consideration of the po...

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Bibliografiske detaljer
Main Authors: Johnson, William D., Muzzio, Miguel, Detrisac, Carol J., Kapetanovic, Izet M., Kopelovich, Levy, McCormick, David L.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195508/
https://ncbi.nlm.nih.gov/pubmed/21864638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2011.08.009
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