CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

Kidney podocytes are highly differentiated epithelial cells that form interdigitating foot processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte injury results in proteinuric kidney disease, and genetic deletion of SD-associated CD2-associated protein (CD2AP) le...

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Main Authors: Yaddanapudi, Suma, Altintas, Mehmet M., Kistler, Andreas D., Fernandez, Isabel, Möller, Clemens C., Wei, Changli, Peev, Vasil, Flesche, Jan B., Forst, Anna-Lena, Li, Jing, Patrakka, Jaakko, Xiao, Zhijie, Grahammer, Florian, Schiffer, Mario, Lohmüller, Tobias, Reinheckel, Thomas, Gu, Changkyu, Huber, Tobias B., Ju, Wenjun, Bitzer, Markus, Rastaldi, Maria P., Ruiz, Phillip, Tryggvason, Karl, Shaw, Andrey S., Faul, Christian, Sever, Sanja, Reiser, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195478/
https://ncbi.nlm.nih.gov/pubmed/21911934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58552
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