Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

In Alzheimer disease (AD), the intracerebral accumulation of amyloid-β (Aβ) peptides is a critical yet poorly understood process. Aβ clearance via the blood-brain barrier is reduced by approximately 30% in AD patients, but the underlying mechanisms remain elusive. ABC transporters have been implicat...

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Detalhes bibliográficos
Main Authors: Krohn, Markus, Lange, Cathleen, Hofrichter, Jacqueline, Scheffler, Katja, Stenzel, Jan, Steffen, Johannes, Schumacher, Toni, Brüning, Thomas, Plath, Anne-Sophie, Alfen, Franziska, Schmidt, Anke, Winter, Felix, Rateitschak, Katja, Wree, Andreas, Gsponer, Jörg, Walker, Lary C., Pahnke, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195473/
https://ncbi.nlm.nih.gov/pubmed/21881209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57867
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