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Structural studies of the PARP-1 BRCT domain
BACKGROUND: Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the first proteins localized to foci of DNA damage. Upon activation by encountering nicked DNA, the PARP-1 mediated trans-poly(ADP-ribosyl)ation of DNA binding proteins occurs, facilitating access and accumulation of DNA repair factors. PA...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3195086/ https://ncbi.nlm.nih.gov/pubmed/21967661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-11-37 |
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