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Meningeal Inflammation Increases Artemether Concentrations in Cerebrospinal Fluid in Papua New Guinean Children Treated with Intramuscular Artemether

Although the artemisinin-associated neurotoxicity identified in vitro and in animal studies has not been confirmed clinically, only one adult study has measured cerebrospinal fluid (CSF) concentrations after administration of conventional doses. Potential artemisinin neurotoxicity could be serious i...

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Detalhes bibliográficos
Main Authors: Manning, Laurens, Laman, Moses, Page-Sharp, Madhu, Salman, Sam, Hwaiwhanje, Ilomo, Morep, Namar, Siba, Peter, Mueller, Ivo, Karunajeewa, Harin A., Davis, Timothy M. E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195017/
https://ncbi.nlm.nih.gov/pubmed/21859936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00375-11
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