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Modulation of Substrate Efflux in Bacterial Small Multidrug Resistance Proteins by Mutations at the Dimer Interface

Bacteria evade the effects of cytotoxic compounds through the efflux activity of membrane-bound transporters such as the small multidrug resistance (SMR) proteins. Consisting typically of ca. 110 residues with four transmembrane (TM) α-helices, crystallographic studies have shown that TM helix 1 (TM...

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Detalhes bibliográficos
Main Authors: Poulsen, Bradley E., Cunningham, Fiona, Lee, Kate K. Y., Deber, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194897/
https://ncbi.nlm.nih.gov/pubmed/21890698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.05846-11
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