Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Transforming Growth Factor (TGF)-β signaling provides tumor protection against colorectal cancer (CRC). Mechanisms that support its tumor suppressive properties remain unclear. The ubiquitin ligase Arkadia/RNF111 enhances TGF-β signaling responses by targeting repressors of the pathway for degradati...

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Detalhes bibliográficos
Main Authors: Sharma, Vikas, Antonacopoulou, Anna G., Tanaka, Shinya, Panoutsopoulos, Alexios A., Bravou, Vasiliki, Kalofonos, Haralabos P., Episkopou, Vasso
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194767/
https://ncbi.nlm.nih.gov/pubmed/21998011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1645
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