P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism

P73 is important in drug-induced apoptosis in some cancer cells, yet its role in the regulation of chemosensitivity in ovarian cancer (OVCA) is poorly understood. Furthermore, if and how the deregulation of p73-mediated apoptosis confers resistance to cisplatin (CDDP) treatment is unclear. Here we d...

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Autori principali: Al-Bahlani, S, Fraser, M, Wong, A Y C, Sayan, B S, Bergeron, R, Melino, G, Tsang, B K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194400/
https://ncbi.nlm.nih.gov/pubmed/21516125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.134
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