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Brain distribution and elimination of recombinant human TIMP-1 after cerebral ischemia and reperfusion in rats

OBJECTIVE: To investigate recombinant human TIMP-1 ((125)I-rhTIMP-1) half-life in blood and its distribution in rat brain tissue after cerebral ischemia/reperfusion as part of a therapeutic development paradigm. METHOD: A suture model of the middle cerebral artery occlusion was used. (125)I-labeled...

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Bibliografiske detaljer
Main Authors: Sa, Yalian, Hao, Jinsong, Samineni, Divya, Clark, Joseph, Pyne-Geithman, Gail, Broderick, Joseph, Lu, Aigang
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193946/
https://ncbi.nlm.nih.gov/pubmed/21535944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1179/1743132810Y.0000000012
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