Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit

The ubiquitously expressed 14-3-3 proteins regulate many pathways involved in transformation. Previously, we found that 14-3-3ζ overexpression increased Akt phosphorylation in human mammary epithelial cells. Here, we investigated the clinical relevance and molecular mechanism of 14-3-3ζ overexpressi...

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Библиографические подробности
Главные авторы: Neal, Christopher L., Xu, Jia, Li, Ping, Mori, Seiji, Yang, Jun, Neal, Nina N., Zhou, Xiaoyan, Wyszomierski, Shannon L., Yu, Dihua
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193867/
https://ncbi.nlm.nih.gov/pubmed/21743495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.284
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