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Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

Human macrophages produce in culture a factor termed mononuclear cell factor (MCF) that increases the production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. A factor with similar biologic activity is also produced by the murine macrophage cell line P388D1. By us...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mizel, S B, Dayer, J M, Krane, S M, Mergenhagen, S E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319369/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6264478/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.4.2474
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