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Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus

The Hedgehog (Hh) family of secreted proteins is essential for development in both vertebrates and invertebrates. As one of main morphogens during metazoan development, the graded Hh signal is transduced across the plasma membrane by Smoothened (Smo) through the differential phosphorylation of its c...

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Autors principals: Zhang, Yanyan, Mao, Feifei, Lu, Yi, Wu, Wenqing, Zhang, Lei, Zhao, Yun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193457/
https://ncbi.nlm.nih.gov/pubmed/21844892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.136
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