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Activated protein C inhibits high mobility group box 1 signaling in endothelial cells
A pathogenic role for high-mobility group box 1 (HMGB1) protein has been postulated in severe sepsis. Activated protein C (APC) is the only drug approved by the Food and Drug Administration for severe sepsis; however, its effect on HMGB1 signaling has never been investigated. Here, we monitored the...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193270/ https://ncbi.nlm.nih.gov/pubmed/21849480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-360701 |
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