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Elevated Hedgehog/Gli signaling causes β-cell dedifferentiation in mice
Although Hedgehog (Hh) signaling regulates cell differentiation during pancreas organogenesis, the consequences of pathway up-regulation in adult β-cells in vivo have not been investigated. Here, we elevate Hh signaling in β-cells by expressing an active version of the GLI2 transcription factor, a m...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193206/ https://ncbi.nlm.nih.gov/pubmed/21969560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105404108 |
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