Competitive Selection from Single Domain Antibody Libraries Allows Isolation of High-Affinity Antihapten Antibodies That Are Not Favored in the llama Immune Response

Single-domain antibodies (sdAbs) found in camelids, lack a light chain and their antigen-binding site sits completely in the heavy-chain variable domain (VHH). Their simplicity, thermostability, and ease in expression have made VHHs highly attractive. While this has been successfully exploited for m...

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Bibliografiske detaljer
Main Authors: Rosa, Sofia Tabares-da, Rossotti, Martin, Carleiza, Carmen, Carrión, Federico, Pritsch, Otto, Ahn, Ki Chang, Last, Jerold A., Hammock, Bruce D, González-Sapienza, Gualberto
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193053/
https://ncbi.nlm.nih.gov/pubmed/21827167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac201824z
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