Recombinant BCG ΔureC hly+ Induces Superior Protection Over Parental BCG by Stimulating a Balanced Combination of Type 1 and Type 17 Cytokine Responses

Background. New vaccines against tuberculosis (TB) are urgently needed because the only available vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG), fails to protect against pulmonary TB in adults. The recombinant ΔureC hly+ BCG (rBCG) is more efficient than parental BCG (pBCG) against pul...

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Main Authors: Desel, Christiane, Dorhoi, Anca, Bandermann, Silke, Grode, Leander, Eisele, Bernd, Kaufmann, Stefan H. E.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Major Articles and Brief Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192191/
https://ncbi.nlm.nih.gov/pubmed/21933877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir592
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