Depurination causes mutations in SOS-induced cells.
Introduction of apurinic sites into phi X174 am3 DNA leads to loss of biological activity when measured in a transfection assay. For single-stranded DNA, approximately one apurinic site constitutes a lethal hit; for double-stranded (RFI) DNA, approximately 3.5 hits per strand are lethal. When the re...
Gespeichert in:
| Veröffentlicht in: | Proc Natl Acad Sci U S A |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1981
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319216/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6453349/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.3.1773 |
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