Maternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase4D5 isozyme and exacerbated Th2 responses; rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammation and atopy

Airway hyperreactivity (AHR), lung inflammation, and atopy are clinical signs of allergic asthma. Gestational exposure to cigarette smoke (CS) markedly increases the risk for childhood allergic asthma. Muscarinic receptors regulate airway smooth muscle tone, and asthmatics exhibit increased AHR to m...

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Bibliographische Detailangaben
Hauptverfasser: Singh, Shashi P., Mishra, Neerad C., Rir-sima-ah, Jules, Campen, Mathew, Kurup, Viswanath, Razani-Boroujerdi, Seddigheh, Sopori, Mohan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191864/
https://ncbi.nlm.nih.gov/pubmed/19596983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900826
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