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Role of GTP hydrolysis in microtubule treadmilling and assembly.

GTP hydrolysis accompanies addition of tubulin to microtubules. I find that hydrolysis is a requirement for the opposite-end assembly/disassembly of microtubules and consequent subunit treadmilling from one end to the other of the polymer. Neither GDP nor guanosine 5'-[beta, gamma-imido]triphos...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteur: Margolis, R L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 1981
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319176/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6940174/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.3.1586
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