Role of GTP hydrolysis in microtubule treadmilling and assembly.
GTP hydrolysis accompanies addition of tubulin to microtubules. I find that hydrolysis is a requirement for the opposite-end assembly/disassembly of microtubules and consequent subunit treadmilling from one end to the other of the polymer. Neither GDP nor guanosine 5'-[beta, gamma-imido]triphosphate...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteur principal: | |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1981
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319176/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6940174/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.3.1586 |
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