Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators

Modulator compounds intended to overcome disease-causing mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) show significant promise in clinical testing for cystic fibrosis. However, the mechanism(s) of action underlying these compounds are not fully understood. Activation o...

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Detalhes bibliográficos
Main Authors: Pyle, Louise C., Ehrhardt, Annette, Mitchell, Lisa High, Fan, LiJuan, Ren, Aixia, Naren, Anjaparavanda P., Li, Yao, Clancy, J. P., Bolger, Graeme B., Sorscher, Eric J., Rowe, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191754/
https://ncbi.nlm.nih.gov/pubmed/21724857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00465.2010
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