Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial

OBJECTIVES: To determine whether polymorphisms at codon 487 (*1, GAA=Glu; *2, AAA=Lys) of mitochondrial aldehyde dehydrogenase 2 (ALDH2) influence nitroglycerine (glyceryl trinitrate (GTN))-induced vasodilation, and whether GTN or isosorbide dinitrate (ISDN) is a more effective antianginal agent in...

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Detalhes bibliográficos
Main Authors: Sakata, Satoko, Yoshihara, Tatsuya, Arima, Hisatomi, Shiraishi, Fumie, Oniki, Hideyuki, Takahashi-Yanaga, Fumi, Matsumura, Kiyoshi, Sasaguri, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2011
Assuntos:
Cardiovascular Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191425/
https://ncbi.nlm.nih.gov/pubmed/22021773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2011-000133
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