Stage-dependent benefits and risks of pimobendan in mice with genetic dilated cardiomyopathy and progressive heart failure

BACKGROUND AND PURPOSE: The Ca(2+) sensitizer pimobendan is a unique inotropic agent that improves cardiac contractility with less of an increase in oxygen consumption and potentially fewer adverse effects on myocardial remodelling and arrhythmia, compared with traditional inotropes. However, clinic...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Nonaka, Miki, Morimoto, Sachio, Murayama, Takashi, Kurebayashi, Nagomi, Li, Lei, Wang, Yuan-Yuan, Arioka, Masaki, Yoshihara, Tatsuya, Takahashi-Yanaga, Fumi, Sasaguri, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403100/
https://ncbi.nlm.nih.gov/pubmed/25560565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13062
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